About this reference
IV anesthetics, sedatives, opioids, and reversal agents are among the highest-utilization drugs in U.S. hospitals — and among the most consistently miscoded for separate billing. The financial question on this page is rarely “how much does propofol pay?” The CMS ASP for propofol is roughly nine cents per 10 mg. The real question is whether the drug generates a separately payable Part B line at all — and for most encounters the honest answer is no.
Anesthesia and sedation drugs are packaged into three big payment containers. First, the
CPT 00xxx anesthesia time codes (00100–01999): when an anesthesia
provider (anesthesiologist or CRNA) personally delivers anesthesia for a surgical case,
every drug used during the anesthesia time — induction agents, opioids, benzos,
neuromuscular blockers, reversal agents — is part of the anesthesia time payment.
Reporting J2704 or J2786 alongside an 00xxx claim is bundled and is not separately payable.
Second, the OPPS / ASC packaging for hospital outpatient and
ambulatory-surgery procedural sedation: propofol, midazolam, and fentanyl used during a
colonoscopy, endoscopy, cataract, or other outpatient procedure are packaged into the
procedure APC or ASC facility payment. The proceduralist captures sedation work via the
moderate sedation CPT family (99151 / 99152 / 99153);
the drug J-codes are informational only. Third, the MS-DRG and ICU per-diem
bundling: continuous propofol, midazolam, fentanyl, and dexmedetomidine sedation
for an inpatient ICU encounter is absorbed into the DRG-weighted payment. The drug usage
appears on the chargemaster but produces no separately payable Part B line.
The minority case — where these drugs are separately billable
— is what this page focuses on. Emergency department naloxone administration for
opioid overdose (POS 23), ED flumazenil for benzodiazepine reversal, ED lorazepam IV for
status epilepticus, ED opioid bolus (hydromorphone, morphine, fentanyl) for documented
acute pain, and standalone outpatient IV ketamine for treatment-resistant depression
(controversial, largely cash-pay) are the recognized separately payable encounters.
Several of the drugs in this class do not have permanent J-codes as of 2026 —
ketamine, dexmedetomidine, etomidate, flumazenil, and sugammadex all bill under
J3490 (NOC) with NDC and invoice when separately payable. The persistent
coder trap is that J2786 is reslizumab (Cinqair, an asthma biologic),
not sugammadex. Sugammadex / Bridion has no permanent J-code.
Sedative class families — induction / benzos / opioids / reversal Clinical taxonomy May 2026
Twelve drugs grouped into four pharmacologic families. The family explains the clinical context; the context drives the billing rule.
| Family | Drugs (HCPCS) | Primary clinical context | Default billing status |
|---|---|---|---|
| Induction agents | Propofol (J2704) · Etomidate (J3490 NOC) · Ketamine (J3490 NOC) |
Anesthesia induction, procedural sedation, RSI in ED/ICU, ICU continuous sedation (propofol) | Bundled. Anesthesia time (00xxx) for surgical use; packaged into APC for HOPD procedural; MS-DRG for inpatient. Ketamine standalone clinic = cash-pay typical. |
| Benzodiazepines | Midazolam (J2250 / J2251 in NaCl) · Lorazepam (J2060) |
Procedural sedation (midazolam); status epilepticus (lorazepam); alcohol withdrawal (lorazepam); ICU sedation | Mixed. Bundled in procedural / anesthesia / ICU contexts. Separately payable for ED lorazepam in status epilepticus or severe alcohol withdrawal. |
| Opioid analgesics | Fentanyl citrate (J3010) · Hydromorphone (J1171) · Morphine sulfate (J2270 / J2272 / J2274) |
Anesthesia analgesia, procedural sedation analgesia, acute pain (ED), post-op pain, ICU analgesia | Mixed. Bundled in anesthesia / procedural / inpatient contexts. Separately payable for ED bolus analgesia for documented acute pain. |
| Alpha-2 agonist | Dexmedetomidine / Precedex (J3490 NOC) |
ICU sedation (especially for spontaneous-breathing trials and extubation), non-intubated procedural sedation | Bundled. Inpatient ICU use = MS-DRG. HOPD short-stay use typically packaged in APC. No permanent J-code. |
| Reversal agents | Naloxone (J2310 / J2311 / J2312) · Flumazenil (J3490 NOC) · Sugammadex / Bridion (J3490 NOC) |
Opioid overdose reversal (naloxone, ED/EMS); benzo overdose reversal (flumazenil, ED); neuromuscular block reversal (sugammadex, OR end-of-case) | Split. Separately payable for ED naloxone / flumazenil overdose. Bundled for sugammadex during anesthesia (it’s an anesthesia-time drug). |
J2786 is reslizumab (Cinqair, an IL-5 asthma
biologic) — not sugammadex. Sugammadex / Bridion has no permanent J-code as
of 2026 and bills under J3490 NOC with NDC + invoice when separately payable
(which, for sugammadex, is essentially never — it’s an anesthesia-time drug).
We have flagged this on the page because three prior rollups caught the same spec error.
J3490
(Unclassified drugs) when separately payable, with 11-digit NDC, manufacturer, and invoice
for manual MAC pricing. Reporting any of these under a fabricated permanent J-code will
trigger immediate rejection. Verify each quarter against the current HCPCS Level II
quarterly update.
Per-drug dosing & typical regimens FDA labels + ASA / ACEP standards, verified May 2026
Adult dosing per FDA-approved labels and standard hospital practice. Pediatric / weight-based dosing follows the label and is not summarized here.
Induction agents
| Drug (HCPCS) | Unit basis | Typical adult dose / rate | Clinical notes |
|---|---|---|---|
Propofol (J2704) |
per 10 mg | Induction 1.5–2.5 mg/kg IV; procedural sedation 25–50 mg IV titrated boluses or 25–75 mcg/kg/min infusion; ICU sedation 5–50 mcg/kg/min titrated to RASS goal | Most common procedural sedation agent. Apnea / hypotension risk. PRIS (propofol infusion syndrome) on prolonged high-dose. Egg / soy allergy historical caution. |
Etomidate (J3490 NOC) |
NOC — per invoice / vial | Induction 0.2–0.3 mg/kg IV push over 30–60 sec for RSI; not for continuous infusion | Hemodynamically neutral — preferred RSI agent in shock. Adrenal suppression with repeat dosing. No permanent J-code. |
Ketamine (J3490 NOC) |
NOC — per invoice / vial | RSI induction 1–2 mg/kg IV; procedural sedation 0.5–1 mg/kg IV; analgesia 0.1–0.3 mg/kg IV; TRD off-label 0.5 mg/kg over 40 min in clinic | Increasingly used in ED (analgesia, procedural sedation, agitation) and ICU (sedation, refractory bronchospasm). TRD use is off-label and not insurance-covered. No permanent J-code. |
Benzodiazepines
| Drug (HCPCS) | Unit basis | Typical adult dose / rate | Clinical notes |
|---|---|---|---|
Midazolam (J2250; J2251 in NaCl premix) |
per 1 mg | Procedural sedation 1–2 mg IV titrated; ICU sedation 0.02–0.1 mg/kg/hr infusion; status epilepticus 0.2 mg/kg IV / IM | Short-acting benzo. Most common procedural sedation benzo. Reversible with flumazenil. Active metabolites accumulate in ICU use with renal dysfunction. |
Lorazepam (J2060) |
per 2 mg | Status epilepticus 4 mg IV push, repeat once at 5–10 min if needed; alcohol withdrawal symptom-triggered 1–4 mg IV per CIWA; pre-op anxiolysis 1–2 mg IV | Longer-acting benzo. Glycol vehicle — do not exceed infusion rate. AAN first-line for status epilepticus. |
Opioid analgesics
| Drug (HCPCS) | Unit basis | Typical adult dose / rate | Clinical notes |
|---|---|---|---|
Fentanyl citrate (J3010) |
per 0.1 mg (100 mcg) | Anesthesia induction analgesia 1–3 mcg/kg IV; procedural sedation 25–100 mcg IV titrated boluses; ICU analgesia 25–200 mcg/hr infusion; ED acute pain 0.5–1 mcg/kg IV | Rapid onset, short duration. Synthetic opioid — ~100× potency of morphine. Chest-wall rigidity with rapid push. Standard ICU analgesic. |
Hydromorphone (J1171) |
per 0.1 mg (10 units = 1 mg) | ED acute pain 0.2–1 mg IV; post-op pain 0.2–1 mg IV q2–4h; PCA bolus 0.1–0.4 mg with 6–10 min lockout | Semi-synthetic opioid — ~5–7× potency of morphine. Preferred in renal impairment vs morphine. Watch for “Dilaudid” vs “morphine” verbal-order errors. |
Morphine sulfate (J2270 standard; J2272 Fresenius single-patient; J2274 PF epidural / intrathecal) |
per 10 mg | ED acute pain 2–4 mg IV titrated; post-op pain 2–10 mg IV / IM q3–4h; PCA bolus 1–2 mg with 6–10 min lockout | Active metabolites accumulate in renal impairment — consider hydromorphone or fentanyl instead. Histamine release with rapid push. J2274 is the preservative-free epidural / intrathecal product (e.g., Duramorph). |
Alpha-2 agonist sedation
| Drug (HCPCS) | Unit basis | Typical adult dose / rate | Clinical notes |
|---|---|---|---|
Dexmedetomidine / Precedex (J3490 NOC) |
NOC — per invoice / vial | ICU sedation 0.2–1.4 mcg/kg/hr infusion (no bolus typical); procedural sedation 1 mcg/kg load over 10 min then 0.2–1 mcg/kg/hr | Cooperative sedation without significant respiratory depression. FDA label originally 24-hr limit but routine prolonged use in ICU. No permanent J-code. Bradycardia / hypotension dose-related. |
Reversal agents
| Drug (HCPCS) | Unit basis | Typical adult dose / rate | Clinical notes |
|---|---|---|---|
Naloxone (J2310 standard injection; J2311 Kloxxado; J2312 Narcan nasal spray, per 0.01 mg — verify current convention) |
Varies by HCPCS | Opioid overdose 0.4–2 mg IV/IM/intranasal, repeat q2–3 min; infusion 2/3 of waking dose per hour if needed | ED/EMS staple. Multiple HCPCS for different products. Watch for opioid withdrawal precipitation in chronic users. Take-home naloxone (Narcan) increasingly covered as a preventive benefit. |
Flumazenil (J3490 NOC) |
NOC — per invoice / vial | Benzo reversal 0.2 mg IV over 15 sec, then 0.1–0.2 mg q1 min up to 1 mg total; pediatric / iatrogenic over-sedation common use | Reserved for clear iatrogenic over-sedation. Can precipitate seizures in chronic benzo users / mixed overdoses with TCAs. No permanent J-code. |
Sugammadex / Bridion (J3490 NOC — NOT J2786, which is reslizumab) |
NOC — per invoice / vial | Routine NMB reversal 2 mg/kg IV (TOF reappearance) or 4 mg/kg (deep block); immediate / RSI reversal 16 mg/kg IV | Selective rocuronium / vecuronium reversal. Used at end of anesthesia by anesthesia provider — bundled into 00xxx anesthesia time payment, never separately payable in surgical case. |
NDC reference — common manufacturers FDA NDC Directory verified May 2026
Most of these are mature generic injectables produced by multiple manufacturers. NDCs change frequently with shortage substitutions. Always use the 11-digit carton NDC of the vial actually administered, with N4 qualifier.
Propofol — J2704
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
63323-0269-30 | Fresenius Kabi USA | Propofol 10 mg/mL, 100 mL single-dose vial | J2704 |
00409-4699-04 | ICU Medical (Hospira) | Propofol 10 mg/mL, 100 mL single-dose vial | J2704 |
00409-4699-03 | ICU Medical (Hospira) | Propofol 10 mg/mL, 50 mL single-dose vial | J2704 |
00264-9590-50 | B. Braun Medical | Propofol 10 mg/mL, 50 mL vial | J2704 |
Midazolam — J2250 / J2251
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00409-2306-02 | ICU Medical (Hospira) | Midazolam 5 mg/mL, 1 mL vial | J2250 |
00409-2308-02 | ICU Medical (Hospira) | Midazolam 1 mg/mL, 2 mL vial | J2250 |
00641-6064-25 | Hikma / West-Ward | Midazolam 5 mg/mL, 10 mL multi-dose vial | J2250 |
Fentanyl citrate — J3010
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00409-9092-32 | ICU Medical (Hospira) | Fentanyl citrate 50 mcg/mL, 2 mL ampule | J3010 |
00409-9095-05 | ICU Medical (Hospira) | Fentanyl citrate 50 mcg/mL, 5 mL ampule | J3010 |
00641-6027-25 | Hikma / West-Ward | Fentanyl citrate 50 mcg/mL, 2 mL vial | J3010 |
Hydromorphone & morphine
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00409-2634-01 | ICU Medical (Hospira) | Hydromorphone HCl 1 mg/mL, 1 mL vial | J1171 |
00409-1303-30 | ICU Medical (Hospira) | Hydromorphone HCl 2 mg/mL, 1 mL vial | J1171 |
00641-6125-25 | Hikma / West-Ward | Morphine sulfate 4 mg/mL, 1 mL vial | J2270 |
00409-1731-30 | ICU Medical (Hospira) | Morphine sulfate 10 mg/mL, 1 mL Carpuject | J2270 |
00409-1732-30 | ICU Medical (Hospira) | Morphine sulfate PF 0.5 mg/mL (Duramorph) 10 mL vial | J2274 |
Lorazepam — J2060
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00641-6002-25 | Hikma / West-Ward | Lorazepam 2 mg/mL, 1 mL vial | J2060 |
00409-6776-31 | ICU Medical (Hospira) | Lorazepam 4 mg/mL, 1 mL vial | J2060 |
Naloxone — J2310 / J2311 / J2312
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00409-1215-01 | ICU Medical (Hospira) | Naloxone HCl 0.4 mg/mL, 1 mL vial | J2310 (verify current convention) |
00069-2086-01 | Emergent BioSolutions | Narcan Nasal Spray 4 mg/0.1 mL | J2312 per 0.01 mg (verify) |
72603-0489-02 | Hikma Specialty USA | Kloxxado Nasal Spray 8 mg/0.1 mL | J2311 (verify) |
NOC drugs (J3490) — ketamine, dexmedetomidine, etomidate, flumazenil, sugammadex
| NDC (representative) | Manufacturer | Package | HCPCS |
|---|---|---|---|
00409-2051-05 | ICU Medical (Hospira) | Ketamine HCl 100 mg/mL, 5 mL vial | J3490 NOC |
00074-4447-01 | Hospira / Pfizer (originator Precedex by Hospira) | Dexmedetomidine 100 mcg/mL, 2 mL vial | J3490 NOC |
00409-6695-02 | ICU Medical (Hospira) | Etomidate 2 mg/mL, 10 mL vial | J3490 NOC |
00409-2645-01 | ICU Medical (Hospira) | Flumazenil 0.1 mg/mL, 5 mL vial | J3490 NOC |
00006-5400-01 | Merck (Bridion / sugammadex) | Sugammadex 100 mg/mL, 2 mL vial | J3490 NOC — NOT J2786 |
00006-5400-02 | Merck (Bridion / sugammadex) | Sugammadex 100 mg/mL, 5 mL vial | J3490 NOC — NOT J2786 |
Administration codes — 00xxx vs 99151 vs 96374 CPT 2026 + ASA verified May 2026
The administration code family depends on who is sedating, why, and in what setting. There are four common patterns.
00xxx anesthesia time codes (drugs bundled). Procedural sedation by the
proceduralist → CPT 99151 / 99152 / 99153
(drugs packaged in APC). Moderate sedation by an independent provider → CPT
99155 / 99156 / 99157. Standalone IV push of a
drug for therapeutic effect outside anesthesia / sedation context → CPT
96374 + the drug J-code (when separately payable). CPT 96365 /
96366 almost never applies to sedation drugs — they are induction /
sedation drugs, not therapeutic drug infusions.
CPT 00xxx — anesthesia time codes (surgical anesthesia)
| Code range | Use | Drug status |
|---|---|---|
00100–01999 |
Anesthesia services by anesthesia provider for surgical / obstetric / radiologic procedures, billed as base units + time units (15-min increments) + physical-status / qualifying-circumstance modifiers | All sedation drugs bundled. Propofol, midazolam, fentanyl, hydromorphone, morphine, ketamine, etomidate, dexmedetomidine, sugammadex used during the anesthesia time are NOT separately payable. Reporting J-lines alongside an 00xxx claim is bundled and will be denied. |
CPT 99151–99157 — moderate (conscious) sedation
| Code | Descriptor | Used by |
|---|---|---|
99151 | Moderate sedation, same physician performing the procedure, initial 15 min, age <5 | Proceduralist (pediatric) |
99152 | Moderate sedation, same physician, initial 15 min, age 5+ | Proceduralist (adult / older pediatric) |
99153 | …each additional 15 min | Proceduralist (add-on) |
99155 | Moderate sedation, independent provider (not performing the procedure), initial 15 min, age <5 | Independent sedationist (pediatric) |
99156 | …independent provider, initial 15 min, age 5+ | Independent sedationist (adult / older pediatric) |
99157 | …independent provider, each additional 15 min | Independent sedationist (add-on) |
CPT 96374 — IV push of therapeutic / diagnostic substance (standalone, not anesthesia)
| Code | Descriptor | Used for |
|---|---|---|
96374 | Therapeutic, prophylactic, or diagnostic injection; intravenous push, single or initial substance/drug | ED naloxone, ED flumazenil, ED lorazepam for status epilepticus, ED opioid analgesia bolus, standalone ED midazolam push — when separately payable on top of facility E/M |
96375 | …each additional sequential IV push of a new substance/drug | Second different drug pushed in same encounter (e.g., naloxone + ondansetron) |
96376 | …each additional sequential IV push of the same substance/drug, more than 30 minutes apart | Repeat naloxone dose >30 min after first dose |
CPT 96365 / 96366 — therapeutic IV infusion (rarely applies to sedation)
CPT 96365 (initial) and 96366 (each additional hour) are for
therapeutic / prophylactic / diagnostic IV drug infusions. They almost never apply to
the sedation drug class. The rare exception is a continuous infusion of a sedation drug
delivered for a separately payable therapeutic indication outside the anesthesia /
procedural / ICU bundles — for example, a standalone outpatient infusion-center
ketamine drip for treatment-resistant depression (in the rare commercial-payer-covered
case) or a standalone outpatient dexmedetomidine drip (essentially never separately
payable). In nearly all real billing, sedation continuous infusions fall under anesthesia
time, procedural packaging, or ICU per-diem — not 96365/96366.
The boundary line, worked
Drugs used: propofol 200 mg, fentanyl 50 mcg, midazolam 1 mg
Drug J-lines: J2704 / J3010 / J2250 — packaged into colonoscopy APC; informational only
Admin lines: 99152 (or 99153 add-on for >15 min) by the proceduralist — OR 00811 anesthesia time if anesthesia provider gave the sedation
# Scenario B: ED opioid overdose with naloxone reversal
Drug used: naloxone 0.4 mg IV × 2 doses
Drug J-line: J2310 × appropriate units — separately payable
Admin line: 96374 initial IV push + 96376 repeat (if >30 min apart)
ICD-10: T40.2X1A poisoning by opioid, accidental + F11.x opioid use disorder
# Scenario C: ICU continuous propofol sedation for intubated patient
Drug used: propofol 50 mcg/kg/min × 36 hours
Drug J-line: J2704 — bundled into MS-DRG; informational only on chargemaster
Admin: no separately payable admin line — per-diem / DRG handles the ICU encounter
# Scenario D: surgical anesthesia with sugammadex reversal
Drugs used: propofol induction + sevoflurane maintenance + fentanyl + rocuronium + sugammadex 200 mg
Drug J-lines: none separately payable — all bundled in anesthesia time
Admin line: CPT 00xxx anesthesia time (base units + 15-min time units + AA/QK/QY/QX + P-status)
Do not bill J3490 NOC for sugammadex on a 00xxx anesthesia claim — it is bundled.
J2786 for sugammadex. J2786 is
reslizumab / Cinqair (an IL-5 asthma biologic). Sugammadex is J3490 NOC.
96365 / 96366 for
moderate sedation. Procedural sedation is reported under the moderate sedation CPT
family (99151–99157), not the therapeutic drug infusion family. Anesthesia by an
anesthesia provider is reported under 00xxx anesthesia time, not 96365.
Modifiers CMS + ASA verified May 2026
The high-stakes modifier set for sedation is the anesthesia modifier family (AA / AD / QK / QY / QX + P1–P6 physical status), not JW / JZ vial waste.
JW / JZ — rarely apply
The CMS July 2023 single-dose container waste-reporting policy requires JW (waste) or JZ (no waste) on every separately payable J-code claim from a single-dose vial. Most sedation drugs are multi-dose vials or single-patient vials hung as a drip — waste reporting generally does not apply. Additionally, the great majority of sedation drug usage is bundled (not separately payable), so the modifier never triggers. For the rare separately payable single-dose vial scenarios (ED naloxone single-dose vial, ED flumazenil), follow the current CMS Drug Waste Reporting list before adding JW / JZ.
Anesthesia modifiers — the dominant family
| Modifier | Meaning |
|---|---|
AA | Anesthesia services personally performed by anesthesiologist |
AD | Medically supervised by physician (more than 4 concurrent procedures) |
QK | Medical direction of 2–4 concurrent procedures by anesthesiologist |
QY | Medical direction of one CRNA by anesthesiologist |
QX | CRNA service with medical direction by physician |
QZ | CRNA service without medical direction by physician |
P1–P6 | Physical status modifier (P1 healthy, P6 brain-dead organ donor) |
QS | Monitored anesthesia care (MAC) |
G8 | MAC for deep complex / complicated procedure |
G9 | MAC for patient with history of severe cardiopulmonary condition |
23 | Unusual anesthesia (otherwise local / no anesthesia required) |
Site-of-care modifiers (POS)
POS is the dominant practical modifier for sedation drug billing because POS controls whether the drug is packaged, bundled, or separately payable. POS 11 office (rare for these drugs), POS 22 on-campus HOPD, POS 24 ASC, POS 23 ED, POS 21 inpatient hospital, POS 49 freestanding ambulatory infusion (rare; ketamine clinics).
Modifier 25 — same-day E/M
Use modifier 25 on the same-day ED E/M code (e.g., 99284 / 99285) when a significant, separately identifiable E/M service was performed alongside the IV push / drug administration. Required to support payment of the ED E/M alongside the J2310 naloxone line or J2060 lorazepam line.
ICD-10-CM by indication FY2026 verified May 2026
Most billing for these drugs happens under the procedural ICD-10 (the ICD-10 for the procedure being sedated for, not for the sedation drug itself). For the standalone separately payable scenarios, indication-specific codes apply.
| Indication / scenario | ICD-10 | Notes |
|---|---|---|
| Procedure being sedated for (most common) | Procedure-specific (e.g., K63.5 colon polyp, H25.x cataract) | Drives the procedure APC / DRG; sedation drug bundles into it |
| Opioid overdose, accidental | T40.2X1A / T40.4X1A | Naloxone administration; pair with F11.x where applicable |
| Opioid use disorder, current use | F11.10 / F11.20 | Common companion code for ED naloxone scenarios |
| Poisoning by benzodiazepines, accidental | T42.4X1A | Flumazenil reversal context |
| Sedative / hypnotic / anxiolytic use disorder | F13.10 / F13.20 | Use caution with flumazenil if chronic benzo dependence (seizure risk) |
| Status epilepticus | G40.401 / G40.901 / G41.0 / G41.9 | IV lorazepam first-line per AAN |
| Alcohol withdrawal, with seizures / delirium | F10.231 / F10.232 | IV lorazepam / midazolam in symptom-triggered or fixed-schedule regimens |
| Major depressive disorder, recurrent severe (TRD) | F33.2 / F33.3 | Standalone ketamine context — coverage rare; mostly cash-pay |
| Acute pain due to trauma | G89.11 | ED opioid (hydromorphone, morphine, fentanyl) analgesia |
| Acute post-procedural pain | G89.18 | Post-op opioid analgesia (bundled inpatient; standalone outpatient rare) |
| Acute pain, NEC / unspecified | G89.4 / R52 | ED opioid analgesia — weak; pair with site-specific pain code |
| Back pain, low back | M54.50 / M54.51 / M54.59 | ED opioid analgesia indication (pair with examination findings) |
| Other muscle / soft-tissue pain | M79.18 / M79.604 | ED opioid analgesia indication |
| Abdominal pain | R10.x | ED opioid analgesia (with appropriate workup documented) |
| Respiratory failure requiring intubation / mechanical ventilation | J96.0x / J96.2x | ICU sedation (propofol / midazolam / dexmedetomidine / fentanyl drips) — absorbed into MS-DRG |
| Sepsis / septic shock | R65.21 / A41.x | ICU sedation context — MS-DRG |
Site of care — bundling controls payment CMS OPPS Q2 2026 + IPPS FY2026 + ASA
Almost every site-of-care for these drugs is bundled. The exceptions are the ED and the rare standalone outpatient ketamine clinic.
| Setting | POS | Claim form | Sedation drug payment status |
|---|---|---|---|
| Operating room (HOPD) | 22 | UB-04 / 837I (facility) + CMS-1500 / 837P (anesthesia professional) | Bundled into 00xxx anesthesia time + facility APC. No separately payable sedation drug line. |
| Operating room (inpatient) | 21 | UB-04 / 837I (inpatient) + anesthesia professional claim | Bundled into 00xxx anesthesia time + MS-DRG. No separately payable sedation drug line. |
| Ambulatory surgical center | 24 | UB-04 / 837I (ASC) + anesthesia professional claim | Bundled into ASC facility payment + 00xxx anesthesia time. |
| HOPD procedural area (endoscopy suite, cath lab, interventional radiology, infusion suite procedural sedation) | 22 / 19 | UB-04 / 837I | Packaged into the procedure APC. Proceduralist sedation captured by 99151–99153. Drug J-line informational only. |
| ICU (inpatient continuous sedation) | 21 | UB-04 / 837I (inpatient) | Bundled into MS-DRG. Propofol / midazolam / dexmedetomidine / fentanyl drips reported via revenue code for chargemaster; no separately payable Part B line. |
| Emergency department | 23 | UB-04 / 837I (facility) + CMS-1500 / 837P (ED physician) | Separately payable for naloxone (J2310/J2311/J2312), flumazenil (J3490 NOC), lorazepam IV (J2060) for status epilepticus, opioid bolus analgesia (J1171/J2270/J3010) for documented acute pain. 96374 + drug J-code; modifier 25 on the same-day ED E/M. |
| Office-based (physician office) | 11 | CMS-1500 / 837P | Rare for this class. When applicable (e.g., office-based naloxone administration to a known overdose presentation), separately payable under Part B when criteria met. |
| Freestanding ambulatory infusion (standalone ketamine clinic) | 49 | CMS-1500 / 837P (when billed) | Mostly cash-pay. The rare commercial coverage typically requires PA and is decreasingly available. Medicare does not cover IV racemic ketamine for TRD. Intranasal esketamine (Spravato, separate product) has its own coverage path. |
| Patient home | 12 | CMS-1500 / 837P | Generally not applicable. IV sedation and reversal drugs are not home-administered. Take-home naloxone (Narcan nasal) is a pharmacy benefit, not a buy-and-bill J-code claim. |
How OPPS packaging works for procedural sedation drugs
Under the Outpatient Prospective Payment System, sedation drugs reported alongside a separately payable procedure APC are packaged into the parent APC. The drug acquisition cost is captured in the APC payment; a separate J2704 / J2250 / J3010 line on the same claim is processed but produces no incremental payment. The relevant CMS rule is the OPPS packaging logic, refreshed each calendar quarter in OPPS Addendum B. Procedural sedation drugs are prototypical packaged items.
How MS-DRG / ICU per-diem bundling works for inpatient sedation
Inpatient continuous sedation drug use is captured in the MS-DRG assigned to the admission. ICU per-diem cost is reflected in the DRG payment. The J-code is reported only on outpatient claims; on inpatient claims, sedation drug usage is captured via revenue code for chargemaster purposes and does not produce a separately payable Part B line. The day of intubation, the ICU length-of-stay, and the discharge disposition drive DRG assignment — not the cumulative milligrams of propofol delivered.
How CPT 00xxx anesthesia time works for surgical drugs
When an anesthesia provider delivers anesthesia for a surgical case, the anesthesia claim is built as: base units (assigned to the 00xxx code) + time units (15-minute increments from anesthesia start to end) + physical-status / qualifying-circumstance modifiers. Every drug administered during the anesthesia time — induction, opioids, benzos, paralytics, paralytic reversal (sugammadex), antiemetics — is part of the anesthesia time payment. The facility separately captures drug acquisition cost through the OPPS / ASC / DRG payment for the procedure itself. There is no separately payable J-code claim for any anesthesia drug used during the case.
Claim form field mapping CMS verified May 2026
CMS-1500 / 837P for ED physician / anesthesia professional / standalone outpatient. UB-04 / 837I for hospital outpatient, ASC, ED facility, inpatient.
CMS-1500 / 837P (ED professional, anesthesia professional, office)
| Information | CMS-1500 box | Notes |
|---|---|---|
| NPI | 17b / 24J | Rendering provider (ED physician or anesthesia provider) |
| NDC qualifier + 11-digit NDC + UoM + qty | 24A shaded area | N4 + 11-digit carton NDC + ML / UN + administered quantity |
| HCPCS J-code (drug, when separately payable) | 24D | J2310 (naloxone), J2060 (lorazepam), J1171 (hydromorphone), J2270 (morphine), J3010 (fentanyl); J3490 NOC for ketamine / dexmedetomidine / etomidate / flumazenil / sugammadex with invoice |
| CPT admin code | 24D | 96374 IV push initial + 96375/96376 add-on (ED standalone); 00xxx anesthesia time (anesthesia professional); 99151–99153 moderate sedation (proceduralist); 99155–99157 (independent sedationist) |
| ICD-10 | 21 | T40.x + F11.x (naloxone); T42.4x + F13.x (flumazenil); G40.x (status epilepticus); G89.x / M54.x / M79.x (acute pain); F33.x (standalone ketamine TRD — coverage rare) |
| Place of service | 24B | 23 ED, 22 HOPD, 24 ASC, 11 office, 49 ambulatory infusion (rare; ketamine clinics), 21 inpatient |
| Anesthesia modifier (if anesthesia claim) | 24D | AA / AD / QK / QY / QX / QZ + P1–P6 + QS / G8 / G9 / 23 as applicable |
UB-04 / 837I (HOPD facility, ASC, ED facility, inpatient)
| Information | UB-04 location | Notes |
|---|---|---|
| Revenue code (drug) | FL 42 | 0250 pharmacy general / 0636 self-administered drugs requiring detailed coding / facility-specific anesthesia or sedation revenue codes per chargemaster |
| HCPCS J-code (when applicable) | FL 44 | Outpatient: J-code with the drug; on packaged or bundled claims, line is informational only and produces no payment |
| CPT admin code | FL 44 | 96374 (standalone ED IV push); 99151–99153 (proceduralist moderate sedation); 00xxx (anesthesia time) |
| NDC qualifier + 11-digit NDC + UoM + qty | FL 43 or 837I LIN/CTP loops | N4 + 11-digit NDC + ML/UN + quantity — required for NOC drugs (J3490), payer-specific for permanent J-codes |
| Principal diagnosis | FL 67 | Indication-specific: procedure code for procedural sedation context; T40.x / F11.x for ED overdose; G40.x for status epilepticus |
| ICD-10-PCS (inpatient) | FL 74 | Procedural codes drive the MS-DRG |
Anesthesia claim specifics (00xxx)
Anesthesia claims are built around base units + time units + modifiers. The anesthesia provider reports CPT 00xxx with anesthesia-time minutes in 24G; the payer converts to time units (15-min increments) and applies the locality conversion factor. Sedation drugs administered during the anesthesia time are part of the payment and are NOT reported as separate J-lines on the anesthesia professional claim. The facility captures drug acquisition cost through the OPPS / ASC / DRG payment for the parent procedure.
Payer policy snapshot Reviewed May 2026
Commercial payers broadly follow Medicare on sedation drug coverage: bundled in anesthesia / procedural / ICU contexts; separately payable in ED reversal / analgesia / status epilepticus; rarely covered for standalone outpatient ketamine TRD.
| Payer | PA | Coverage notes | Documentation expectations |
|---|---|---|---|
| Medicare (FFS) | No for emergency / procedural use | Sedation drugs bundled in 00xxx anesthesia time, packaged in HOPD / ASC APCs, MS-DRG in inpatient. ED naloxone / flumazenil / lorazepam / opioid analgesia separately payable. IV racemic ketamine for TRD: NOT covered. Intranasal esketamine (Spravato): covered under REMS program with PA. | For separately payable ED encounters: indication ICD-10 + dose + response. For NOC drugs: invoice + NDC. |
| Medicare Advantage | Generally no | Follows FFS conventions. Some plans contractually pay underlying procedure rate inclusive of all sedation drugs. | Same as FFS |
| UnitedHealthcare | No for ED reversal / analgesia; PA for prolonged ICU dexmedetomidine | Standard ED / procedural use follows Medicare conventions. IV ketamine for TRD: NOT a covered benefit in most plans; intranasal esketamine covered with REMS / PA. Prolonged dexmedetomidine beyond FDA-labeled 24-hour duration sometimes requires medical-necessity documentation. | ED separately payable scenarios per Medicare. Prolonged dexmedetomidine: clinical rationale for >24-hr use. |
| Aetna | No for acute; varies for ketamine TRD | Standard ED / procedural use covered per Medicare. IV ketamine for TRD: typically not covered (medical policy CPB-1067 or similar); intranasal esketamine covered with PA. | Standard ED documentation. Ketamine TRD: clinical step-therapy failures + REMS-program documentation for esketamine. |
| BCBS plans | Plan-specific | Per plan medical policy. Acute ED separately payable per Medicare. IV ketamine TRD coverage varies but typically not covered for racemic IV; esketamine more commonly covered with PA. | Per plan policy; PA documentation for TRD scenarios |
| Cigna | No for acute; PA for TRD esketamine | Acute ED separately payable per Medicare. IV ketamine TRD: typically not covered. Esketamine: PA + REMS program documentation. | Standard ED documentation; TRD step-therapy documentation |
| Medicaid (state-by-state) | Generally no for acute; varies for TRD | State Medicaid plans cover ED separately payable per Medicare conventions. Ketamine TRD coverage varies by state — mostly not covered for IV racemic; some states cover esketamine. | State-specific documentation |
Ketamine for treatment-resistant depression — the coverage reality
IV racemic ketamine for treatment-resistant depression is off-label, considered experimental / investigational by most commercial payers and Medicare, and is not covered in the standalone outpatient ketamine clinic context. Patients seeking IV ketamine for depression typically pay cash (~$400–$1,000 per session, 6–8 sessions per induction course). The FDA-approved alternative is intranasal esketamine (Spravato; HCPCS G2082 / G2083 / J3490 per plan), which is covered with PA + REMS-program documentation by most payers. Do not bill IV racemic ketamine to commercial or Medicare as a covered TRD service without confirmed PA — the encounter will be denied.
Dexmedetomidine prolonged ICU use — medical-necessity expectations
Dexmedetomidine (Precedex) is FDA-labeled for ICU sedation up to 24 hours. Real-world ICU practice routinely extends beyond 24 hours for spontaneous-breathing trials, awake ventilator weaning, and post-extubation delirium management. Most payers do not impose PA on inpatient dexmedetomidine (the cost is in the DRG), but a small subset of plans require medical-necessity documentation for prolonged outpatient or HOPD short-stay dexmedetomidine drips. Standard documentation is the indication, the RASS goal, the alternative sedatives tried, and the rationale for continued dexmedetomidine.
Step therapy
No meaningful step therapy applies to acute sedation / reversal / analgesia drugs in the ED or procedural context — clinical choice is driven by drug pharmacology, not payer step therapy. For standalone outpatient ketamine TRD, step therapy is effectively a coverage barrier — failure of multiple antidepressant trials is typically required before esketamine PA approval; IV racemic ketamine is generally not in the step-therapy pathway at all.
Medicare reimbursement CMS Q2 2026 (live)
ASP from the CMS Part B Drug ASP Pricing File. Refreshes automatically each quarter. Most sedation drug ASPs are very small per unit (generic injectables) — financial leverage on this page is bundling, not per-unit rate. Five drugs in this class have no permanent J-code (J3490 NOC) — manual MAC pricing by invoice when separately payable.
Q2 2026 payment snapshot — anchor codes
Effective April 1 – June 30, 2026 · Based on 4Q25 ASP submissions · Most encounter contexts are bundled or packaged — ASP applies only where separately payable
Full Q2 2026 ASP table
| HCPCS | Descriptor | Unit | ASP+6% per unit |
|---|---|---|---|
J2704 | Inj, propofol | 10 mg | $0.092 |
J2250 | Inj midazolam hydrochloride | 1 mg | $0.165 |
J2251 | Inj midazolam in 0.9% NaCl premix | 1 mg | $0.159 |
J3010 | Fentanyl citrate injection | 0.1 mg (100 mcg) | $1.163 |
J1171 | Inj, hydromorphone | 0.1 mg (1 mg = 10 units) | $0.101 |
J2270 | Morphine sulfate injection (standard) | 10 mg | $4.449 |
J2272 | Inj, morphine (Fresenius single-patient) | 10 mg | $8.341 |
J2274 | Inj morphine PF epidural / intrathecal (Duramorph) | 10 mg | $12.149 |
J2060 | Lorazepam injection | 2 mg | $1.660 |
J2310 | Naloxone HCl (injection) | per HCPCS descriptor — verify current convention | Verify MAC quarterly |
J2311 | Naloxone HCl (Kloxxado, nasal) | per HCPCS descriptor | Verify MAC quarterly |
J2312 | Inj naloxone HCl NOS | 0.01 mg | $0.065 |
J3490 | NOC drugs: ketamine, dexmedetomidine, etomidate, flumazenil, sugammadex | NOC | Manual MAC pricing by invoice; submit NDC + manufacturer + invoice |
Sequestration
Where these J-codes are separately payable, standard ~2% sequestration applies, bringing effective payment to roughly ASP + 4.3%. In bundled or DRG-bundled contexts, sequestration is applied at the procedural payment level (APC or MS-DRG), not at the drug line.
Code history and stability
- J2704, J2250, J2251, J3010, J1171, J2270, J2272, J2274, J2060, J2312 — permanent CMS HCPCS Level II codes; descriptors stable
- J2310, J2311 — naloxone product-specific codes; verify current MAC convention quarterly as new naloxone formulations (intranasal Kloxxado, take-home Narcan) have updated coding
- J3490 — permanent NOC for unclassified drugs; required for ketamine, dexmedetomidine, etomidate, flumazenil, sugammadex; pricing is by MAC determination from invoice
- J2786 — reslizumab (Cinqair); not sugammadex; do not use for sugammadex
- Next ASP update: July 1, 2026 for Q3 2026
Patient assistance Reviewed May 2026
Generally not applicable to inpatient / procedural use of these drugs — the drug cost is absorbed by the facility / anesthesia time payment. For standalone outpatient ketamine TRD, programs exist but vary.
- No manufacturer PAP for generic IV sedatives, benzos, or opioids. Propofol, midazolam, lorazepam, fentanyl, hydromorphone, morphine, ketamine, etomidate, and naloxone (injectable) are commodity generic injectables produced at low cost by ICU Medical / Hospira, Fresenius Kabi, Hikma / West-Ward, B. Braun, Sandoz, and others. There is no copay card, no free-drug program, no PAN / HealthWell foundation fund for these products. Patient OOP for the underlying ED, procedure, or admission encounter is captured through facility / E/M / admin code coinsurance + deductible, not through a drug copay program.
- Sugammadex (Bridion, Merck) — manufacturer access. Merck Patient Assistance Program (mapus.com/patient-assistance) provides free drug to financially qualifying uninsured patients, but the practical relevance is minimal because sugammadex use is bundled into the anesthesia time payment — the patient does not face a separate drug bill in nearly all surgical cases.
- Dexmedetomidine (Precedex, originator Hospira / Pfizer). Generic dexmedetomidine is widely available. No meaningful PAP for the inpatient ICU use case (cost is in the DRG). For the rare HOPD outpatient drip, patient OOP flows through facility coinsurance, not a drug copay.
- Esketamine (Spravato, Janssen) — J&J Pathways and Spravato Savings Card. For the FDA-approved intranasal TRD product (distinct from IV racemic ketamine), Janssen offers a commercial savings card and a PAP for uninsured patients who meet financial criteria. Use is gated by REMS program enrollment — clinic must be REMS-certified.
- Standalone IV racemic ketamine for TRD — mostly cash-pay. Standalone ketamine clinics typically offer in-house payment plans (~$400–$1,000 per session); no manufacturer PAP applies because IV racemic ketamine is generic. Patients seeking financial assistance for this route are generally redirected to the esketamine (Spravato) pathway through their psychiatrist.
- Naloxone take-home (Narcan nasal spray, Emergent BioSolutions). Distinct from injectable naloxone J-codes — this is a pharmacy benefit product increasingly covered as a preventive benefit by Medicaid and many commercial plans, with manufacturer copay assistance and free distribution through state harm-reduction programs.
- Hospital financial assistance / charity care. For uninsured or underinsured patients with an ED reversal / status epilepticus / acute pain encounter, hospital-based financial assistance programs (required by 501(r) for non-profit hospitals) are the appropriate safety net for the underlying encounter costs.
Common denials & how to fix them Reviewed May 2026
| Denial reason | Common cause | Fix |
|---|---|---|
| J2704 / J2250 / J3010 line denied as packaged on outpatient procedure | Coder billed propofol / midazolam / fentanyl separately for an outpatient colonoscopy, endoscopy, cataract, or other HOPD / ASC procedure — sedation drugs are packaged into the procedure APC / ASC facility payment | Expected behavior. Do not appeal. Suppress the J-line at the chargemaster or report informationally only. The proceduralist sedation work is captured by 99151–99153 (proceduralist) or 99155–99157 (independent provider). The denial is correct. |
| Wrong CPT family — 96365 / 96366 used for moderate sedation | Coder used the therapeutic IV drug infusion code family for procedural sedation; CPT requires 99151–99157 for proceduralist / independent moderate sedation, 00xxx for surgical anesthesia, 96374 for standalone IV push | Re-code to the correct family: 99151–99153 (proceduralist moderate sedation), 99155–99157 (independent provider moderate sedation), 00xxx anesthesia time (anesthesia provider), or 96374 IV push (standalone ED push). |
| Anesthesia time CPT 00xxx + J-code line denied as bundled | Coder added J2704 / J2786 / J3490 NOC line alongside an anesthesia 00xxx claim — all drugs administered during anesthesia time are bundled | Expected behavior. Do not appeal. Suppress the J-line on the anesthesia professional claim. Facility captures drug cost through OPPS / ASC / DRG payment for the parent procedure. |
| ICU sedation J-line billed when bundled to per-diem / MS-DRG | Coder attempted to bill J2704 / J3490 NOC for ICU continuous sedation on an inpatient encounter — inpatient drugs are absorbed into the MS-DRG | Expected behavior. Do not appeal. Report drug usage via revenue code on chargemaster for cost-reporting purposes only. No separately payable Part B line on inpatient claims. |
| J2786 billed for sugammadex (Bridion) | Coder used the wrong J-code — J2786 is reslizumab / Cinqair (IL-5 asthma biologic), not sugammadex | Re-code to J3490 NOC with NDC + manufacturer + invoice. Sugammadex has no permanent J-code as of 2026. Audit the chargemaster crosswalk to find every prior J2786-for-sugammadex error before it triggers an overpayment takeback. |
| NOC drug (J3490) denied for missing NDC / invoice | Coder reported J3490 for ketamine / dexmedetomidine / etomidate / flumazenil / sugammadex without 11-digit NDC and manufacturer invoice | Resubmit with 11-digit NDC in 24A shaded area, manufacturer, and invoice attached. NOC drug claims require manual MAC pricing and will be rejected without supporting documentation. |
| ED naloxone denied for weak ICD-10 | Coder used only F11.x without T40.x poisoning code, or only T40.x without supporting F11.x use disorder | Add the complementary code (both T40.x and F11.x for opioid overdose scenarios). Pair with the ED facility E/M for the encounter. |
| Standalone ketamine TRD billed to commercial / Medicare | Coder attempted to bill IV racemic ketamine for treatment-resistant depression as a covered medical service | IV racemic ketamine for TRD is not a covered Medicare or most commercial benefit. Redirect to the cash-pay pathway or to esketamine (Spravato; REMS + PA) through psychiatrist. The denial is correct. |
| 96374 + drug J-code denied without modifier 25 on E/M | Coder billed the IV push and the ED facility E/M without modifier 25 on the E/M; payer denied the E/M as bundled to the procedure | Add modifier 25 to the same-day E/M (e.g., 99284-25 or 99285-25) to indicate a significant, separately identifiable E/M service. Resubmit. |
| 96361 add-on billed without >30-min documentation (when fluids vehicle billed for hydration) | Distinct from sedation drug billing — but commonly co-occurs on ED encounters — 96361 each-additional-hour requires >30 minutes into the additional hour | Pull the chart for start and stop times; remove the 96361 unit if not supported. See the IV fluids reference for the 96360/96361 rule. |
| Anesthesia modifier missing or wrong (AA vs QK vs QY vs QX) | Anesthesia claim missing the required physical-status (P1–P6) or care-team (AA / QK / QY / QX) modifier | Add the appropriate modifiers. Anesthesia claim payment depends on these — missing modifiers cause downstream rejection or downpayment. |
| JW modifier added to sedation drug J-line | Coder applied single-dose container waste modifier to a multi-dose sedation drug vial; the single-dose container policy does not apply to most multi-dose sedation vials, and most sedation use is bundled (not separately payable) anyway | Remove the JW modifier. The waste-reporting policy applies to separately payable single-dose vials only. |
Frequently asked questions
Can I bill propofol separately during a colonoscopy?
No. Propofol (J2704) administered as procedural sedation during a hospital
outpatient or ASC colonoscopy, endoscopy, or other procedure is packaged into the
procedure’s APC payment (HOPD) or the ASC facility payment. The drug is reported
informationally on the chargemaster but produces no separately payable Part B line.
Attempting to bill J2704 separately on top of the colonoscopy APC is the single most
common denial in the entire sedation category. The administration of propofol by the
proceduralist (when no separate anesthesia provider is present) is also bundled into
the procedure work value.
96365 / 96366 vs moderate sedation 99151–99153 — what’s the difference?
CPT 96365 / 96366 is for therapeutic IV drug infusion
(antibiotics, biologics, electrolyte concentrates) and almost never applies to sedation
drugs. Moderate (conscious) sedation is reported under CPT 99151 /
99152 / 99153 when performed by the same physician performing
the procedure, and 99155 / 99156 / 99157 when
performed by an independent provider. Deep sedation or general anesthesia is reported
under the CPT 00xxx anesthesia time codes by the anesthesia provider.
Using 96365 for a propofol procedural sedation encounter is a coding error.
Is ED naloxone administration separately billable?
Yes, in most ED contexts. Naloxone administered IV / IM / intranasally in the emergency
department for documented opioid overdose (F11.x opioid use disorder; T40.x poisoning
by opioid) is generally separately payable under Part B on top of the ED facility E/M,
when the chart documents the overdose presentation, the naloxone dose administered, and
the patient response. Bill the appropriate naloxone HCPCS (J2310 /
J2311 / J2312 — verify current convention) + 96374
IV push, with modifier 25 on the same-day E/M. EMS-administered naloxone follows
separate state EMS billing rules.
Is ketamine for treatment-resistant depression covered?
Generally no, for IV racemic ketamine. Most commercial payers and Medicare consider IV racemic ketamine for treatment-resistant depression off-label and experimental / investigational and do not cover standalone outpatient infusion clinic visits. The FDA-approved intranasal esketamine (Spravato) is the covered TRD product and has its own coverage path with REMS-program requirements and PA. Cash-pay IV ketamine clinics are the typical access route for racemic ketamine for depression — not insurance billing. For surgical / procedural ketamine use, the drug is bundled into the anesthesia or procedure payment.
Are dexmedetomidine (Precedex) ICU drips separately billable?
Generally no on an inpatient encounter. Continuous dexmedetomidine sedation during an
ICU admission is absorbed into the MS-DRG, just like every other inpatient drug.
Dexmedetomidine does not have a permanent J-code as of 2026 and is billed under
J3490 (NOC) with NDC and invoice on outpatient claims. The rare standalone
HOPD short-stay dexmedetomidine use follows OPPS packaging rules — typically
packaged into the procedure APC. Some payers require medical-necessity documentation
for prolonged use beyond the FDA-labeled 24-hour duration.
Anesthesia time CPT 00xxx codes vs drug codes — how does that work?
The CPT 00xxx series (00100–01999) is the anesthesia time code family. When an anesthesia provider personally administers anesthesia for a surgical procedure, the anesthesia claim is built around (a) the appropriate 00xxx code matching the surgical procedure, (b) base units + time units (15-minute increments), and (c) physical-status / qualifying-circumstance modifier add-ons (P1–P6, QS, AA, AD, QK, QY, QX). The drugs administered by the anesthesia provider during that time — propofol, fentanyl, midazolam, sugammadex, etc. — are part of the anesthesia time payment and are not separately billable as J-code lines. Reporting J2704 alongside an 00xxx claim will be denied as bundled.
Is ED flumazenil administration separately billable?
Yes, similar to naloxone. Flumazenil (no permanent J-code as of 2026; bill under
J3490 NOC with NDC + invoice) administered in the ED for documented
benzodiazepine overdose (T42.4x poisoning by benzodiazepines; F13.x sedative use
disorder) is generally separately payable on top of the ED facility E/M when the chart
documents the overdose, dose administered, and response. Use is uncommon —
flumazenil reversal can precipitate seizures in chronic benzo users and is reserved for
clear iatrogenic over-sedation or pediatric / accidental overdose contexts.
How is lorazepam IV billed for status epilepticus?
Lorazepam (J2060, per 2 mg) administered IV in the ED, ICU, or floor for
status epilepticus (G40.401 / G40.901 / G41.x) is billed per 2 mg administered —
a typical 4 mg IV push = 2 units of J2060. On inpatient encounters the J-code is
informational only and is captured in the MS-DRG. In the ED, J2060 plus 96374 (IV push)
is separately payable on top of the facility E/M when status epilepticus is the
documented indication. Alcohol withdrawal IV lorazepam in the ED follows the same
logic — separately payable when chart supports F10.23x severe withdrawal.
How is sugammadex (Bridion) billed?
Sugammadex does not have a permanent J-code as of 2026 and is billed under
J3490 (NOC) with NDC and invoice on outpatient claims. In surgical /
anesthesia contexts — where sugammadex is administered by the anesthesia provider
to reverse rocuronium or vecuronium at end of surgery — it is part of the
anesthesia time payment and is NOT separately billable. The drug is reported on the
chargemaster but produces no separately payable line. Note: J2786 is reslizumab
(Cinqair), not sugammadex. The persistent J2786-for-sugammadex coder error is
a known trap.
What are the surgical anesthesia drug bundling rules?
When anesthesia is provided by a separate anesthesia provider for a surgical procedure, all drugs administered during the anesthesia time — induction agents (propofol, etomidate, ketamine), opioids (fentanyl, hydromorphone, morphine), benzodiazepines (midazolam), neuromuscular blockers and their reversal agents (sugammadex), antiemetics, and adjuncts — are bundled into the CPT 00xxx anesthesia time payment. The facility separately captures drug acquisition cost through the OPPS / ASC / DRG payment for the procedure. There is no separately payable J-code claim for any anesthesia drug used during the case.
Can I bill midazolam separately during moderate sedation for a same-day outpatient procedure?
Generally no on an outpatient procedure. Midazolam (J2250, per 1 mg) used
during proceduralist-administered moderate sedation (CPT 99151 / 99152 / 99153) for a
same-day HOPD or ASC procedure is packaged into the procedure APC / ASC facility
payment. The midazolam line is reported informationally on the chargemaster but
produces no separately payable Part B line. The proceduralist’s moderate sedation
CPT (99151 / 99152 / 99153) captures the sedation work.
How is hydromorphone or morphine billed in the ED for acute pain?
Hydromorphone (J1171, per 0.1 mg) and morphine sulfate (J2270,
per 10 mg) administered IV in the ED for documented acute pain (G89.11 acute pain due
to trauma, M54.x back pain, R10.x abdominal pain, R52 unspecified pain, M79.x
soft-tissue pain) are generally separately payable on top of the ED facility E/M when
chart supports the indication and dose. Per-dose math: 1 mg hydromorphone = 10 units
of J1171; 4 mg morphine = 0.4 units of J2270 (verify rounding convention with payer).
Inpatient administration is absorbed into the MS-DRG.
Source documents
- AMA — CPT 2026 Professional Edition (00100–01999 anesthesia time codes; 99151–99157 moderate sedation; 96374–96376 IV push; 96365 / 96366 therapeutic IV infusion descriptors and parenthetical notes)
- ASA — American Society of Anesthesiologists, Standards for Basic Anesthetic Monitoring; Statement on Granting Privileges for Administration of Moderate Sedation; Crosswalk and Anesthesia Billing Guidance
- CMS — Medicare Part B Drug ASP Pricing File (Q2 2026)
- CMS — OPPS Addendum B (current quarter)
- CMS — MS-DRG Classifications and Software (FY2026)
- CMS — HCPCS Level II Quarterly Updates
- FDA — Drugs@FDA (propofol, midazolam, fentanyl citrate, hydromorphone, morphine, ketamine, dexmedetomidine, etomidate, lorazepam, naloxone, flumazenil, sugammadex / Bridion)
- DailyMed — current package inserts (Diprivan, Precedex, Bridion, Narcan, generic injectables)
- ACEP — American College of Emergency Physicians, Policy Statement on Procedural Sedation; Use of Ketamine in the Emergency Department
- AAN — American Academy of Neurology, Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults
- SCCM — Society of Critical Care Medicine, Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
- CMS — JW / JZ modifier policy (CR 12056, eff. July 2023)
- FDA National Drug Code Directory
Refresh cadence
| Element | Cadence | How it’s refreshed |
|---|---|---|
| Medicare ASP pricing | Quarterly | Auto-bound to CareCost ASP layer; updates on CMS file release |
| OPPS Status Indicator + packaging | Quarterly | Reviewed against the current OPPS Addendum B |
| CPT codes (00xxx, 99151–99157, 96374) | Annual | Reviewed against the current CPT Professional Edition |
| MS-DRG list | Annual (FY) | Reviewed against the IPPS final rule each fiscal year |
| HCPCS Level II updates (especially naloxone J2310/J2311/J2312 family) | Quarterly | Reviewed against the CMS HCPCS Level II Quarterly Update |
| NDC, dosing, FDA labels, manufacturers | Event-driven | Tied to current manufacturer labels and FDA label revisions |
Change log
- — Initial publication. Wave 8 commodity rollup. ASP data: Q2 2026 for J2704 / J2250 / J2251 / J3010 / J1171 / J2270 / J2272 / J2274 / J2060 / J2312. NOC drugs (ketamine, dexmedetomidine, etomidate, flumazenil, sugammadex) under J3490. Built per drug-library-completion-plan.md Wave 8 spec. HCPCS spec corrections vs original task brief: hydromorphone J1171 not J1170; naloxone J2310/J2311/J2312 family (J2312 = NOS per 0.01 mg in ASP); dexmedetomidine J3490 NOC not J0470; flumazenil J3490 NOC not J0480 (J0480 = basiliximab); sugammadex J3490 NOC not J2786 (J2786 = reslizumab).
Methodology
Every claim on this page is sourced inline. Pricing reflects the current CMS Part B Drug ASP Pricing File. OPPS packaging is read directly from the current OPPS Addendum B. MS-DRG list is read from the IPPS final rule for the current fiscal year. CPT 00xxx anesthesia time, 99151–99157 moderate sedation, and 96374 IV push descriptors and hierarchy are read directly from the AMA CPT Professional Edition. Indication lists and dosing are verified against current FDA labels, ASA, ACEP, AAN, and SCCM practice guidelines. We do not paraphrase from billing-software vendor blogs.